I'm not sure how I feel about this. I'm not vehemently opposed to a sequel, but I've never been in the camp that desired one either.
On second thought, the more I think about this ( Prometheus coming to mind)...
Harrison Ford, you should probably channel your Han Solo instincts on this one.
Edit: This is important to note:
It's still unclear if Ridley Scott will direct the new Blade Runner movie, but it's looking increasingly likely that he won't.