For me it would be cyborgs/androids. I know this is ridiculous and unrealistic but I still like it. Though when did spine plugs become a thing?
Rachael. A woman deprived of a past and as a Replicant she has no future. Truly a tragic story.
Adam Jensen. Struggling to reconcile his human nature and the technology his life depends on.
Major Motoko Kusanagi. Due to an accident as a child, Motoko was outfitted with a prosthetic body. In this way she was able to transcend conventional ideas of the body and of the self.